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| specificities & advantages |
cardiovascular model |
The specific and differentiating properties of the Biovays in vitro cardiovascular model offer new possibilities for testing your candidates. These may be summarised as follows:
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| | > | | | the primary endothelial and muscular cell culture is the closest model to in situ cells reproducing a functional cardiovascular endothelium and muscularis |
| | > | | | the possibility to investigate your candidates in vitro on a functional endothelium and muscularis using combined immunofluorescent, molecular and biochemical methods |
| | > | | | allows us to study the effect of your candidates on the interactions of endothelial cells with monocytes for immunological responses and inflammatory reactions (adhesion assay) |
| | > | | | assessment of mediators (and receptors) expressed by endothelial and muscular cardiovascular cells such as endothelin-1, cGMP, nitric oxide synthase, angiotensin II, surface adhesion molecules, prostacyclin… |
| | > | | | assessment of mediators and receptors expressed during inflammation by endothelial and muscular cardiovascular cells (ICAM-1, VCAM-1) |
| | > | | | possibility to investigate the effects of candidates through the internalisation of up to 3 GPCRs simultaneously in endothelial or muscular cells using the patented Biovays ImagePro software |
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